Sugi Predict

Sugi Predict / Compounds / SCHEMBL17544206

SCHEMBL17544206

SCHEMBL17544206

COc1cnc(COc2ccc3[nH]c(-c4cccnc4)nc3c2)cn1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 5/20 0.50
▸ ALDH1A1 P00352 5/20 0.50
▸ RAB9A P51151 5/20 0.50
▸ HPGD P15428 4/20 0.50
▸ NPC1 O15118 4/20 0.50
▸ SMN1; SMN2 Q16637 4/20 0.50
▸ MAPT P10636 3/20 0.50
▸ STAT1 P42224 1/20 0.50
▸ LDHA P00338 1/20 0.46
▸ EPHX2 P34913 1/20 0.46
▸ PRMT5 O14744 1/20 0.43
▸ CYP11B1 P15538 3/20 0.42
▸ HTT P42858 1/20 0.42
▸ KIT P10721 2/20 0.41
▸ NPY5R Q15761 2/20 0.40
▸ HSD17B10 Q99714 3/20 0.39
▸ TP53 P04637 2/20 0.39
▸ TSHR P16473 2/20 0.39
▸ NFKB1 P19838 2/20 0.39
▸ NFKB2 Q00653 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30402163 1.00 KDM4E (0.50) KDM4EALDH1A1RAB9AHPGDNPC1
SCHEMBL19428531 0.92 RAB9A (0.50) KDM4EALDH1A1RAB9AHPGDNPC1
SCHEMBL19428499 0.79 MAPT (0.54) KDM4EALDH1A1RAB9AHPGDNPC1
SCHEMBL19432719 0.78 KDM4E (0.55) KDM4EALDH1A1RAB9AHPGDNPC1
SCHEMBL17543999 0.78 TSHR (0.55) KDM4EALDH1A1RAB9AHPGDNPC1
SCHEMBL29680788 0.78 TSHR (0.55) KDM4EALDH1A1RAB9AHPGDNPC1
SCHEMBL29680837 0.77 CYP11B1 (0.45) MAPTCYP11B1KITCYP19A1CYP11B2
SCHEMBL17544140 0.77 CYP11B1 (0.45) MAPTCYP11B1KITCYP19A1CYP11B2
SCHEMBL19428521 0.77 KDM4E (0.51) KDM4EALDH1A1RAB9AHPGDNPC1
SCHEMBL29680779 0.75 CYP11B1 (0.53) MAPTCYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 — — US claimed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US claimed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US claimed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP claimed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO claimed
US-12258355-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2025-03-25 — — US disclosed
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2024-09-10 — — US disclosed
CN-116655618-A Probes for imaging huntingtin CHDI基金会股份有限公司 2023-08-29 — — CN disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
CN-107108534-B Probes for imaging huntingtin CHDI基金会股份有限公司 2023-05-09 — — CN disclosed
US-20220409600-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF CHDI FOUNDATION, INC. 2022-12-29 — — US disclosed
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 KDM4E 4585/4885ALDH1A1 3976/4885RAB9A 1100/4885
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 KDM4E 2698/4885ALDH1A1 3950/4885RAB9A 1054/4885
US-10479802-B2 Probes for imaging huntingtin protein HTT, HYPK, FABP7 KDM4E 4674/4885ALDH1A1 3949/4885RAB9A 993/4885
US-20220409600-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF HTT, HYPK, UBQLN2 KDM4E 2698/4885ALDH1A1 3950/4885RAB9A 1054/4885
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 KDM4E 4585/4885ALDH1A1 3976/4885RAB9A 1100/4885
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, FABP7 KDM4E 4674/4885ALDH1A1 3949/4885RAB9A 993/4885
US-12258355-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 KDM4E 4585/4885ALDH1A1 3976/4885RAB9A 1100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.