Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 16/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 16/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 12/20 | 0.43 |
| ▸ | TSHR | P16473 | 11/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.42 |
| ▸ | USP2 | O75604 | 8/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.42 |
| ▸ | CASP1 | P29466 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17544827 | 0.81 | CYP2C19 (0.42) | CYP1A2CYP3A4ALDH1A1HSD17B10TSHR | |
| SCHEMBL17544745 | 0.80 | CYP1A2 (0.41) | CYP1A2CYP3A4ALDH1A1HSD17B10TSHR | |
| SCHEMBL17544773 | 0.71 | L3MBTL1 (0.39) | CYP1A2CYP3A4ALDH1A1HSD17B10TSHR | |
| SCHEMBL10235421 | 0.70 | MAPK1 (0.33) | ALDH1A1HSD17B10TSHRMAPK1CYP2C19 | |
| SCHEMBL27528035 | 0.70 | HSP90AA1 (0.46) | ALDH1A1HSD17B10TSHRLMNAHPGD | |
| SCHEMBL24442277 | 0.68 | ALDH1A1 (0.35) | CYP1A2CYP3A4ALDH1A1HSD17B10TSHR | |
| SCHEMBL11164347 | 0.67 | CYP1A2 (0.45) | CYP1A2CYP3A4ALDH1A1HSD17B10TSHR | |
| SCHEMBL10233670 | 0.66 | ALDH1A1 (0.39) | CYP1A2CYP3A4ALDH1A1HSD17B10TSHR | |
| SCHEMBL91161 | 0.66 | — | — | |
| SCHEMBL266418 | 0.65 | RAB9A (0.54) | ALDH1A1HSD17B10TSHRMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9802941-B2 | Compounds and methods for inhibiting histone demethylases | GILEAD SCIENCES, INC. (US) | 2017-10-31 | — | — | US | disclosed |
| CN-107074807-A | Compositions and methods for inhibiting histone demethylase | 吉利德科学公司 | 2017-08-18 | — | — | CN | disclosed |
| EP-3186238-A1 | COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-07-05 | — | — | EP | disclosed |
| US-20160102096-A1 | COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES | EPITHERAPEUTICS APS | 2016-04-14 | — | — | US | disclosed |
| WO-2016033169-A1 | COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES | EPITHERAPEUTICS APS (US) | 2016-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102096-A1 | COMPOUNDS AND METHODS FOR INHIBITING HISTONE DEMETHYLASES | PHF8, KDM3A, PHF2 | CYP1A2 1743/4885CYP3A4 3198/4885ALDH1A1 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.