Sugi Predict

Sugi Predict / Compounds / SCHEMBL17544709

SCHEMBL17544709

SCHEMBL17544709

O=C(Nc1ccccc1O)C1CC1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 5/20 0.60
▸ KMT2A Q03164 3/20 0.60
▸ MEN1 O00255 2/20 0.60
▸ PKM P14618 1/20 0.57
▸ CETP P11597 1/20 0.56
▸ HDAC3 O15379 1/20 0.56
▸ HDAC1 Q13547 1/20 0.56
▸ HDAC2 Q92769 1/20 0.56
▸ ALDH1A1 P00352 3/20 0.54
▸ NPSR1 Q6W5P4 2/20 0.52
▸ EPHX2 P34913 1/20 0.52
▸ HPGD P15428 3/20 0.52
▸ NPC1 O15118 2/20 0.52
▸ LMNA P02545 1/20 0.52
▸ TP53 P04637 1/20 0.52
▸ HTT P42858 1/20 0.52
▸ MAPT P10636 1/20 0.51
▸ GFER P55789 1/20 0.51
▸ SMN1; SMN2 Q16637 2/20 0.51
▸ HSD17B10 Q99714 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29721597 1.00 GAA (0.60) GAAKMT2AMEN1PKMCETP
SCHEMBL19423434 0.91 CETP (0.69) GAAKMT2ACETPHDAC3HDAC1
SCHEMBL28734434 0.91 CETP (0.69) GAAKMT2ACETPHDAC3HDAC1
SCHEMBL16112823 0.85 KMT2A (0.49) GAAKMT2AMEN1CETPHDAC3
SCHEMBL28592805 0.81 CYP2C19 (0.64) GAAKMT2AMEN1PKMCETP
SCHEMBL28669892 0.79 NPC1 (0.63) GAAKMT2AMEN1PKMCETP
SCHEMBL28256532 0.79 GAA (0.55) GAAKMT2AMEN1PKMCETP
SCHEMBL13342791 0.79 TDP1 (0.60) GAAPKMCETPHDAC3HDAC1
SCHEMBL28019517 0.79 GAA (0.55) GAAKMT2AMEN1PKMCETP
SCHEMBL4744831 0.79 SMN1; SMN2 (0.67) GAAKMT2AMEN1PKMCETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114380709-B Synthesis method of 4-chloro-2-acylaminophenol 西北农林科技大学 2023-07-21 — — CN disclosed
EP-4070795-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME Salk Institute for Biological Studies (US) 2022-10-12 — — EP disclosed
CN-114380709-A Synthesis method of 4-chloro-2-acylaminophenol 西北农林科技大学 2022-04-22 — — CN disclosed
EP-3185868-B1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INST FOR BIOLOGICAL STUDI (US) 2022-04-06 — — EP disclosed
US-10774092-B2 ULK1 inhibitors and methods using same SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2020-09-15 — — US disclosed
US-10774092-B2 ULK1 inhibitors and methods using same SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2020-09-15 — — US disclosed
US-10689397-B2 ULK1 inhibitors and methods using same SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2020-06-23 — — US disclosed
US-10689397-B2 ULK1 inhibitors and methods using same SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2020-06-23 — — US disclosed
US-20190284207-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES 2019-09-19 — — US disclosed
US-20190284207-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES 2019-09-19 — — US disclosed
US-20190248806-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES 2019-08-15 — — US disclosed
US-20190152989-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES 2019-05-23 — — US disclosed
US-20190152989-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES 2019-05-23 — — US disclosed
US-10266549-B2 ULK1 inhibitors and methods using same SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2019-04-23 — — US disclosed
US-10266549-B2 ULK1 inhibitors and methods using same SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2019-04-23 — — US disclosed
US-20170342088-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2017-11-30 — — US disclosed
US-20170342088-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2017-11-30 — — US disclosed
EP-3185868-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME Salk Institute for Biological Studies (US) 2017-07-05 — — EP disclosed
WO-2016033100-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2016-03-03 — — WO disclosed
WO-2016033100-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2016-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10689397-B2 ULK1 inhibitors and methods using same ULK1, ULK2, ULK3 GAA 523/4885KMT2A 3395/4885MEN1 1586/4885
US-10266549-B2 ULK1 inhibitors and methods using same ULK1, ULK2, ULK3 GAA 523/4885KMT2A 3395/4885MEN1 1586/4885
US-20170342088-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME ULK1, ULK2, ULK3 GAA 546/4885KMT2A 3500/4885MEN1 2139/4885
US-20190248806-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME ULK1, ULK2, ULK3 GAA 546/4885KMT2A 3500/4885MEN1 2139/4885
US-20190152989-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME ULK1, ULK2, ULK3 GAA 546/4885KMT2A 3500/4885MEN1 2139/4885
US-10774092-B2 ULK1 inhibitors and methods using same ULK1, ULK2, ULK3 GAA 523/4885KMT2A 3395/4885MEN1 1586/4885
US-20190284207-A1 NOVEL ULK1 INHIBITORS AND METHODS USING SAME ULK1, ULK2, ULK3 GAA 546/4885KMT2A 3500/4885MEN1 2139/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.