Sugi Predict

Sugi Predict / Compounds / SCHEMBL17544799

SCHEMBL17544799

SCHEMBL17544799

O=C(Nc1ccc2oc(-c3cccnc3)nc2c1)c1cc2ccccc2o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 1.00
▸ L3MBTL1 Q9Y468 2/20 1.00
▸ PTK2B Q14289 1/20 1.00
▸ MAPT P10636 13/20 0.74
▸ TP53 P04637 3/20 0.74
▸ KDM4E B2RXH2 6/20 0.73
▸ HPGD P15428 3/20 0.73
▸ NPC1 O15118 2/20 0.73
▸ RAB9A P51151 2/20 0.73
▸ HSD17B10 Q99714 3/20 0.72
▸ NPSR1 Q6W5P4 2/20 0.72
▸ POLB P06746 4/20 0.72
▸ RXFP1 Q9HBX9 4/20 0.71
▸ SMN1; SMN2 Q16637 1/20 0.71
▸ USP2 O75604 2/20 0.68
▸ ESR1 P03372 1/20 0.67
▸ MEN1 O00255 1/20 0.67
▸ LMNA P02545 1/20 0.67
▸ TSHR P16473 1/20 0.67
▸ KMT2A Q03164 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30427299 1.00 ALDH1A1 (1.00) ALDH1A1L3MBTL1PTK2BMAPTTP53
SCHEMBL2248127 0.85 KDM4E (0.89) ALDH1A1L3MBTL1PTK2BMAPTTP53
SCHEMBL2246906 0.84 MAPT (1.00) ALDH1A1L3MBTL1PTK2BMAPTTP53
SCHEMBL2248459 0.84 KDM4E (1.00) ALDH1A1L3MBTL1PTK2BMAPTTP53
SCHEMBL19428465 0.84 TP53 (0.80) ALDH1A1L3MBTL1PTK2BMAPTTP53
SCHEMBL16383845 0.84 MAPT (1.00) ALDH1A1L3MBTL1PTK2BMAPTTP53
SCHEMBL2245746 0.83 MAPT (0.83) ALDH1A1L3MBTL1PTK2BMAPTTP53
SCHEMBL17544322 0.83 KDM4E (0.71) ALDH1A1L3MBTL1PTK2BMAPTTP53
SCHEMBL30426788 0.83 KDM4E (0.71) ALDH1A1L3MBTL1PTK2BMAPTTP53
SCHEMBL29000625 0.82 KDM4E (0.77) ALDH1A1L3MBTL1PTK2BMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US claimed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US claimed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP claimed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO claimed
US-12258355-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2025-03-25 — — US disclosed
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2024-09-10 — — US disclosed
CN-116655618-A Probes for imaging huntingtin CHDI基金会股份有限公司 2023-08-29 — — CN disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
CN-107108534-B Probes for imaging huntingtin CHDI基金会股份有限公司 2023-05-09 — — CN disclosed
US-20220409600-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF CHDI FOUNDATION, INC. 2022-12-29 — — US disclosed
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 ALDH1A1 3976/4885L3MBTL1 3337/4885PTK2B 3815/4885
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 ALDH1A1 3950/4885L3MBTL1 200/4885PTK2B 3507/4885
US-10479802-B2 Probes for imaging huntingtin protein HTT, HYPK, FABP7 ALDH1A1 3949/4885L3MBTL1 3244/4885PTK2B 3821/4885
US-20220409600-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF HTT, HYPK, UBQLN2 ALDH1A1 3950/4885L3MBTL1 200/4885PTK2B 3507/4885
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 ALDH1A1 3976/4885L3MBTL1 3337/4885PTK2B 3815/4885
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, FABP7 ALDH1A1 3949/4885L3MBTL1 3244/4885PTK2B 3821/4885
US-12258355-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 ALDH1A1 3976/4885L3MBTL1 3337/4885PTK2B 3815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.