Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 2/20 | 0.51 |
| ▸ | CTSD | P07339 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2090954 | 0.80 | MAPT (0.45) | POLBNOS3NOS1NOS2SIGMAR1 | |
| SCHEMBL1754212 | 0.78 | SIGMAR1 (0.50) | CTSDNOS3NOS1NOS2SIGMAR1 | |
| SCHEMBL10047202 | 0.76 | NOS3 (0.39) | DPP8DPP9DPP7DPP4NOS3 | |
| SCHEMBL2090375 | 0.76 | NOS3 (0.41) | CTSDDPP8DPP9DPP7DPP4 | |
| SCHEMBL1754463 | 0.75 | PRMT5 (0.43) | DPP8DPP9DPP7DPP4NOS3 | |
| SCHEMBL6867120 | 0.68 | RYR2 (1.00) | RYR2POLBHTTHTR1ANPSR1 | |
| SCHEMBL2090957 | 0.67 | SIGMAR1 (0.41) | CTSDDPP8DPP9DPP7DPP4 | |
| SCHEMBL15090906 | 0.65 | SIGMAR1 (0.40) | CTSDDPP8DPP9DPP7DPP4 | |
| SCHEMBL15090844 | 0.64 | SIGMAR1 (0.39) | CTSDDPP8DPP9DPP7DPP4 | |
| SCHEMBL15090847 | 0.64 | SIGMAR1 (0.41) | CTSDDPP8DPP9DPP7DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673898-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2014-03-18 | — | — | US | claimed |
| EP-1928845-B1 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC (US) | 2013-07-10 | — | — | EP | claimed |
| US-20120208801-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (US) | 2012-08-16 | — | — | US | claimed |
| US-8163738-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2012-04-24 | — | — | US | claimed |
| US-20080306050-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (CO) | 2008-12-11 | — | — | US | claimed |
| EP-1928845-A2 | AMINODIAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Array Biopharma, Inc. (US) | 2008-06-11 | — | — | EP | claimed |
| WO-2007040840-A2 | AMINODIAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | ARRAY BIOPHARMA INC. (US) | 2007-04-12 | — | — | WO | claimed |
| US-8673898-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8673898-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2014-03-18 | — | — | US | disclosed |
| US-8673898-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2014-03-18 | — | — | US | disclosed |
| EP-1928845-B1 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC (US) | 2013-07-10 | — | — | EP | disclosed |
| EP-1928845-B1 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC (US) | 2013-07-10 | — | — | EP | disclosed |
| US-20120208801-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-8163738-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163738-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163738-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20080306050-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (CO) | 2008-12-11 | — | — | US | disclosed |
| US-20080306050-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (CO) | 2008-12-11 | — | — | US | disclosed |
| US-20080306050-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (CO) | 2008-12-11 | — | — | US | disclosed |
| WO-2007040840-A2 | AMINODIAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | ARRAY BIOPHARMA INC. (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208801-A1 | Aminodiazepines as Toll-Like Receptor Modulators | TLR8, TLR1, TLR5 | RYR2 628/4885CTSD 2484/4885POLB 4184/4885 |
| US-20080306050-A1 | Aminodiazepines as Toll-Like Receptor Modulators | TLR8, TLR1, TLR5 | RYR2 628/4885CTSD 2484/4885POLB 4184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.