Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11126131 | 0.80 | TSHR (0.38) | CYP2C19KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL3802806 | 0.76 | CYP2C19 (0.36) | CYP2C19KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL2488648 | 0.76 | CYP2C19 (0.36) | CYP2C19KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL252297 | 0.76 | CYP3A4 (0.37) | CYP2C19KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL5603510 | 0.75 | ALDH1A1 (0.39) | KDM4EMAPTCYP3A4LMNAHPGD | |
| SCHEMBL2950286 | 0.74 | CYP2C19 (0.35) | CYP2C19KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL11211725 | 0.73 | CYP2D6 (0.37) | CYP2C19KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL3291158 | 0.72 | SLC6A4 (0.39) | CYP2C19KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL17616783 | 0.72 | CYP2C19 (0.34) | CYP2C19KDM4EMAPTCYP3A4ALOX15 | |
| SCHEMBL4865335 | 0.72 | SRD5A2 (0.42) | CYP2C19KDM4EMAPTCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907359-A2 | 3,5-SUBSTITUTED PIPERIDINE DERIVATIVES EFFECTIVE ON RENIN-RELATED DISORDERS | Novartis AG (CH) | 2008-04-09 | — | — | EP | claimed |
| WO-2007006534-A2 | PIPERIDINE DERIVATIVES USEFUL IN THE DIAGNOSTIC AND THERAPEUTIC TREATMENT OF DISEASES DEPENDING ON RENIN ACTIVITY | NOVARTIS AG (CH) | 2007-01-18 | — | — | WO | claimed |
| CN-115087660-A | Synthetic triterpenoids with nitrogen-based substituents at C-17 and methods of use thereof | 里亚塔医药公司 | 2022-09-20 | — | — | CN | disclosed |
| EP-1948643-A2 | 3-ALKYL-5- (4-ALKYL-5-OXO-TETRAHYDROFURAN-2-YL) PYRROLIDIN-2-ONE DERIVATIVES AS INTERMEDIATES IN THE SYNTHESIS OF RENIN INHIBITORS | Novartis AG (CH) | 2008-07-30 | — | — | EP | disclosed |
| EP-1896411-A2 | PROCESS FOR PREPARING RENIN INHIBITORS | Novartis AG (CH) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007045420-A2 | 3-ALKYL-5- (4-ALKYL-5-OXO-TETRAHYDROFUTRAN-2-YL) PYRROLIDIN-2-ONE DERIVATIVES AS INTERMEDIATES IN THE SYNTHESIS OF RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-04-26 | — | — | WO | disclosed |
| WO-2006131304-A2 | PROCESS FOR PREPARING RENIN INHIBITORS | NOVARTIS AG (CH) | 2006-12-14 | — | — | WO | disclosed |
| EP-0690861-A1 | SUBSTITUTED HETEROANNULATED IMIDAZOLES AND THEIR USE AS HERBICIDES | BAYER AG (DE) | 1996-01-10 | — | — | EP | disclosed |
| EP-0667861-A1 | 2-FLUOROALKYL-SUBSTITUTED BENZIMIDAZOLES, THEIR PREPARATION AND THEIR USE AS PESTICIDES | BAYER AG (DE) | 1995-08-23 | — | — | EP | disclosed |
| WO-1995007022-A1 | FUNGICIDES | ZENECA LIMITED (GB) | 1995-03-16 | — | — | WO | disclosed |
| US-4873301-A | Optically active, ethylenically unsaturated polymers of amino penicillanic acid compounds | M & D RESEARCH CO., LTD. (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0281234-A1 | Optically active, ethylenically unsaturated monomers and polymers thereof | M & D RESEARCH CO., LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |
| US-4721787-A | CONDENSATION, REDUCTION, DEHYDRATION | CIBA-GEIGY CORPORATION (US) | 1988-01-26 | — | — | US | disclosed |
| US-4692469-A | 2-BENZYL-3-(SUBSTITUTED)-PHENOXYPROPYLAMINES; APPETITE SUPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1987-09-08 | — | — | US | disclosed |
| US-4604397-A | Certain benzo-(pyrano and thiopyrano)-pyridines, useful as CNS agents | CIBA-GEIGY CORPORATION (US) | 1986-08-05 | — | — | US | disclosed |
| US-4588746-A | Propylamine derivatives | CIBA-GEIGY CORPORATION (US) | 1986-05-13 | — | — | US | disclosed |
| US-4500472-A | CYCLIZATION, DEHYDRATION OF 1-(2-IMIDAZO-2-YLTHIO) PHENYLIMINO THIOCARBONYL) PIPERAZINE) | CIBA-GEIGY CORPORATION (US) | 1985-02-19 | — | — | US | disclosed |
| US-4477379-A | NEUROLEPTIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1984-10-16 | — | — | US | disclosed |
| US-4444688-A | NEUROLEPTICS | CIBA-GEIGY CORPORATION (US) | 1984-04-24 | — | — | US | disclosed |
| US-4391808-A | NEUROLEPTIC AND ANTIPSYCHOTIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-07-05 | — | — | US | disclosed |