SCHEMBL1754894

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL5356773	0.87	BRAF (0.46)	BRAFKDRIDH1RAF1
	SCHEMBL5363478	0.85	BRAF (0.45)	BRAFKDRIDH1RAF1STK25
	SCHEMBL1754862	0.83	BRAF (0.46)	BRAFKDRIDH1RAF1
	SCHEMBL4556886	0.80	BRAF (0.43)	BRAFKDRIDH1RAF1
	SCHEMBL5359860	0.73	BRAF (0.44)	BRAFKDRIDH1
	SCHEMBL12413879	0.72	PTGES (0.46)	BRAFKDRRAF1STK25CIT
	SCHEMBL12413884	0.71	PTGES (0.42)	BRAFKDRRAF1
	SCHEMBL5365202	0.71	BRAF (0.53)	BRAFKDRIDH1
	SCHEMBL4556565	0.71	BRAF (0.57)	BRAFKDRIDH1
	SCHEMBL12413902	0.68	PTGES (0.42)	BRAFMET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.