Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 8/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.57 |
| ▸ | IKBKB | O14920 | 4/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 3/20 | 0.41 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754919 | 0.96 | ROCK1 (0.53) | ROCK1ROCK2IKBKBPRKCZCCR2 | |
| SCHEMBL1754935 | 0.84 | IKBKB (0.46) | ROCK1ROCK2IKBKBPRKCZCHUK | |
| SCHEMBL1705194 | 0.83 | ROCK1 (0.54) | ROCK1ROCK2IKBKBPRKCZCCR2 | |
| SCHEMBL1705741 | 0.83 | ROCK1 (0.54) | ROCK1ROCK2IKBKBPRKCZCCR2 | |
| SCHEMBL1705000 | 0.83 | ROCK1 (0.54) | ROCK1ROCK2IKBKBPRKCZCCR2 | |
| SCHEMBL1705714 | 0.81 | IKBKB (0.54) | ROCK1ROCK2IKBKBPRKCZCHUK | |
| SCHEMBL1705260 | 0.81 | IKBKB (0.54) | ROCK1ROCK2IKBKBPRKCZCHUK | |
| SCHEMBL12192827 | 0.79 | ROCK1 (0.76) | ROCK1ROCK2IKBKBPRKCZCCR2 | |
| SCHEMBL1754929 | 0.78 | LMNA (0.43) | ROCK1ROCK2IKBKBPRKCZPRMT3 | |
| SCHEMBL1705239 | 0.78 | ROCK1 (0.57) | ROCK1ROCK2IKBKBPRKCZCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125746-B1 | CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE DERIVATIVES | SANOFI SA (FR) | 2012-04-18 | — | — | EP | disclosed |