Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRMT3 | O60678 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754933 | 0.84 | ROCK1 (0.57) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL1754919 | 0.82 | ROCK1 (0.53) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL1754929 | 0.78 | LMNA (0.43) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL1705714 | 0.74 | IKBKB (0.54) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL1705260 | 0.74 | IKBKB (0.54) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL1705061 | 0.74 | IKBKB (0.53) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL2335181 | 0.74 | IKBKB (0.53) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL1705060 | 0.74 | IKBKB (0.53) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL19002700 | 0.73 | CYP19A1 (0.48) | ROCK1ROCK2PRMT3CYP19A1 | |
| SCHEMBL1705154 | 0.73 | PRMT3 (0.50) | IKBKBPRKCZROCK1ROCK2PRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125746-B1 | CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE DERIVATIVES | SANOFI SA (FR) | 2012-04-18 | — | — | EP | disclosed |