Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 6/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 3/20 | 0.37 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704777 | 0.85 | LMNA (0.43) | LMNAIKBKBPRKCZROCK1MMP13 | |
| SCHEMBL1754933 | 0.78 | ROCK1 (0.57) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL1754935 | 0.78 | IKBKB (0.46) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL1754919 | 0.77 | ROCK1 (0.53) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL1092530 | 0.74 | LMNA (0.54) | LMNAMMP13ADAM17MEN1KMT2A | |
| SCHEMBL1705714 | 0.70 | IKBKB (0.54) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL1705260 | 0.70 | IKBKB (0.54) | IKBKBPRKCZROCK1ROCK2PRMT3 | |
| SCHEMBL1704728 | 0.67 | IKBKB (0.62) | IKBKBPRKCZROCK1ROCK2 | |
| SCHEMBL102335 | 0.66 | MMP13 (0.44) | LMNAMMP13MEN1KMT2AMMP14 | |
| SCHEMBL30824363 | 0.66 | ROCK1 (0.72) | IKBKBPRKCZROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125746-B1 | CYCLOALKYLAMINE SUBSTITUTED ISOQUINOLINE DERIVATIVES | SANOFI SA (FR) | 2012-04-18 | — | — | EP | disclosed |