Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.71 |
| ▸ | POLB | P06746 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 9/20 | 0.70 |
| ▸ | MEN1 | O00255 | 8/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | CLK1 | P49759 | 2/20 | 0.69 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.67 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.67 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.67 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.67 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17107189 | 0.83 | RAB9A (1.00) | RAB9APOLBNPC1MEN1KMT2A | |
| SCHEMBL17551125 | 0.82 | RAB9A (0.80) | RAB9APOLBNPC1MEN1KMT2A | |
| SCHEMBL17549350 | 0.78 | SMN1; SMN2 (0.60) | RAB9APOLBNPC1MEN1KMT2A | |
| SCHEMBL28594556 | 0.76 | CSNK2A1 (0.67) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL93095 | 0.76 | ALDH1A1 (0.75) | RAB9APOLBNPC1MEN1KMT2A | |
| SCHEMBL17551124 | 0.76 | MAPT (0.73) | RAB9APOLBNPC1MEN1KMT2A | |
| SCHEMBL28583306 | 0.75 | NPC1 (0.69) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL8402291 | 0.75 | MAPT (0.73) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL17549351 | 0.75 | MEN1 (0.62) | RAB9APOLBNPC1MEN1KMT2A | |
| SCHEMBL17551132 | 0.75 | KLK7 (1.00) | RAB9APOLBNPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951055-B2 | Thiazole-based inhibitors of scavenger receptor BI | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2018-04-24 | — | — | US | disclosed |
| US-9951055-B2 | Thiazole-based inhibitors of scavenger receptor BI | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2018-04-24 | — | — | US | disclosed |
| US-20160060254-A1 | THIAZOLE-BASED INHIBITORS OF SCAVENGER RECEPTOR BI | THE BROAD INSTITUTE, INC. | 2016-03-03 | — | — | US | disclosed |
| US-20160060254-A1 | THIAZOLE-BASED INHIBITORS OF SCAVENGER RECEPTOR BI | THE BROAD INSTITUTE, INC. | 2016-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060254-A1 | THIAZOLE-BASED INHIBITORS OF SCAVENGER RECEPTOR BI | SCARB1, HAVCR2, LDLR | RAB9A 2900/4885POLB 2738/4885NPC1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.