Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | CDC7 | O00311 | 7/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008984 | 0.78 | ALDH1A1 (0.59) | MAPTLMNAKDM4EMEN1ALDH1A1 | |
| SCHEMBL22423310 | 0.77 | CYP2A6 (0.53) | MAPTLMNAKDM4EAURKAALDH1A1 | |
| SCHEMBL15568639 | 0.75 | HDAC8 (1.00) | HDAC8CDC7GCGRPDPK1MAPT | |
| SCHEMBL9052074 | 0.75 | ATAD2 (0.48) | MAPTLMNAKDM4EMEN1ALDH1A1 | |
| SCHEMBL8350984 | 0.75 | ERCC1 (0.47) | MAPK14MAPTLMNAKDM4EMEN1 | |
| SCHEMBL8356630 | 0.75 | ALDH1A1 (0.48) | GCGRMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL30527121 | 0.74 | CCNC (0.47) | CDC7PDE3BPDE3ACYP3A4CYP2C9 | |
| SCHEMBL13977458 | 0.69 | GCGR (0.74) | HDAC8CDC7MAPK14GCGRPDPK1 | |
| SCHEMBL7536764 | 0.67 | BTK (0.51) | MAPTLMNAKDM4EALDH1A1CYP1A2 | |
| SCHEMBL17797070 | 0.67 | SMN1; SMN2 (0.68) | HDAC8CDC7PDE3BPDE3AGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160060679-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-03 | — | — | US | disclosed |
| US-20160060679-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060679-A1 | COMPOUNDS, SUBSTRATES AND METHODS RELATED TO HISTONE DEACETYLASES | HDAC1, HDAC11, HDAC10 | HDAC8 20/4885CDC7 2064/4885PDE3B 4430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.