Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.44 |
| ▸ | GCK | P35557 | 2/20 | 0.42 |
| ▸ | GCKR | Q14397 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29437363 | 0.86 | GPR119 (0.55) | TRPC6GPR119MAPTMEN1TSHR | |
| SCHEMBL29426702 | 0.84 | MAPT (0.56) | TRPC6GPR119MAPTMEN1TSHR | |
| SCHEMBL1393764 | 0.84 | MAPT (0.56) | TRPC6GPR119MAPTMEN1TSHR | |
| Ammonia Solution, Strong SCHEMBL28415331 | 0.83 | GPR119 (0.55) | TRPC6GPR119MAPTMEN1TSHR | |
| SCHEMBL26641577 | 0.83 | MAPT (0.58) | TRPC6GPR119MAPTMEN1TSHR | |
| SCHEMBL1990159 | 0.80 | CKS1B (0.53) | TRPC6GPR119MAPTMEN1TSHR | |
| SCHEMBL30316131 | 0.80 | CKS1B (0.53) | TRPC6GPR119MAPTMEN1TSHR | |
| SCHEMBL21152690 | 0.79 | TRPC6 (0.45) | TRPC6GCKGCKRGPR119MAPT | |
| SCHEMBL30643550 | 0.78 | GPR119 (0.52) | TRPC6GPR119MAPTMEN1TSHR | |
| SCHEMBL26641386 | 0.78 | GPR119 (0.52) | TRPC6GPR119MAPTMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016030439-A1 | METHOD OF PRODUCING PALBOCICLIB AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | RATIOPHARM GMBH (DE) | 2016-03-03 | — | — | WO | disclosed |