Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 16/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14137117 | 0.88 | DGAT1 (0.69) | DGAT1 | |
| SCHEMBL17552048 | 0.85 | DGAT1 (0.65) | DGAT1 | |
| SCHEMBL14061844 | 0.83 | DGAT1 (0.40) | DGAT1 | |
| SCHEMBL14137101 | 0.80 | DGAT1 (0.38) | DGAT1ALDH1A1 | |
| SCHEMBL14061745 | 0.75 | DGAT1 (0.83) | DGAT1 | |
| SCHEMBL17551967 | 0.73 | DGAT1 (0.59) | DGAT1PARP10PARP11 | |
| SCHEMBL14137086 | 0.70 | DGAT1 (0.67) | DGAT1 | |
| SCHEMBL17460907 | 0.69 | DGAT1 (0.88) | DGAT1 | |
| SCHEMBL629836 | 0.69 | SMN1; SMN2 (0.53) | DGAT1ALDH1A1 | |
| SCHEMBL6979410 | 0.69 | PARP10 (0.55) | DGAT1PARP10PARP11HRH3ASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2723332-B1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2016-03-02 | — | — | EP | disclosed |