Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 12/20 | 0.74 |
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.52 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.49 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.49 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | LTK | P29376 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755624 | 0.86 | KARS1 (0.79) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL902707 | 0.85 | SYK (0.76) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL902728 | 0.82 | KARS1 (1.00) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL4903188 | 0.81 | KARS1 (0.64) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL4902836 | 0.80 | KARS1 (0.62) | KARS1SYKMEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL4904575 | 0.80 | KARS1 (0.62) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL10268092 | 0.80 | KARS1 (1.00) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL901241 | 0.80 | KARS1 (1.00) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL13136558 | 0.80 | KARS1 (0.58) | KARS1SYKMEN1NPC1RAB9A | |
| SCHEMBL902909 | 0.80 | KARS1 (0.63) | KARS1SYKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |