Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755647 | 0.88 | PIK3CD (0.45) | PTGS2PIK3CDPIK3CACYP1A2GPR119 | |
| SCHEMBL11925494 | 0.82 | PTGS2 (0.43) | PTGS2PIK3CDPIK3CACYP1A2GPR119 | |
| SCHEMBL8091771 | 0.81 | PIK3CD (0.51) | PIK3CDPIK3CA | |
| SCHEMBL11924823 | 0.79 | PTGS2 (0.43) | PTGS2 | |
| SCHEMBL11926064 | 0.78 | PIK3CD (0.46) | PTGS2PIK3CDPIK3CACYP1A2GPR119 | |
| SCHEMBL11925445 | 0.74 | PIK3CA (0.42) | PTGS2PIK3CDPIK3CACYP1A2GPR119 | |
| SCHEMBL737776 | 0.73 | PIK3CA (0.67) | PIK3CDPIK3CA | |
| SCHEMBL1755671 | 0.73 | ALDH1A1 (0.39) | PTGS2PIK3CDPIK3CA | |
| SCHEMBL11925541 | 0.72 | PTGS2 (0.43) | PTGS2PIK3CDPIK3CACYP1A2GPR119 | |
| SCHEMBL11926045 | 0.72 | MEN1 (0.52) | PIK3CACYP1A2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176238-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2012-04-18 | — | — | EP | disclosed |