Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 7/20 | 0.40 |
| ▸ | CA1 | P00915 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755671 | 0.85 | ALDH1A1 (0.39) | PIK3CDPIK3CAKMT2ACA2CA1 | |
| SCHEMBL1755647 | 0.82 | PIK3CD (0.45) | PIK3CDPIK3CAGAAKMT2ACA2 | |
| SCHEMBL8217050 | 0.81 | NAMPT (0.42) | PIK3CDPIK3CAMTOR | |
| SCHEMBL11925440 | 0.81 | CA2 (0.42) | PIK3CDPIK3CAKMT2ACA2CA1 | |
| SCHEMBL1755697 | 0.81 | PTGS2 (0.44) | PIK3CDPIK3CA | |
| SCHEMBL739807 | 0.79 | PIK3CA (0.83) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8217617 | 0.79 | PIK3CA (0.41) | PIK3CDPIK3CAGAACA2CA1 | |
| SCHEMBL8095008 | 0.79 | CA1 (0.53) | PIK3CDPIK3CAKMT2ACA2CA1 | |
| SCHEMBL8092498 | 0.78 | PIK3CD (0.49) | PIK3CDPIK3CAGAAKMT2ACA2 | |
| SCHEMBL8219081 | 0.78 | NAMPT (0.43) | PIK3CDPIK3CAKMT2AALDH1A1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007750-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |