Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 3/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL481040 | 0.86 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL481193 | 0.86 | MAPT (0.53) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL1755719 | 0.85 | MAPT (0.44) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL10245317 | 0.84 | MAPT (0.51) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL1755718 | 0.84 | GRM2 (0.41) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL1755744 | 0.82 | SMPD1 (0.41) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL481620 | 0.79 | MAPT (0.48) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL27705271 | 0.78 | MAPT (0.53) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 | |
| SCHEMBL481470 | 0.77 | CYSLTR1 (0.64) | CYSLTR1GRM2CYSLTR2MRGPRX4 | |
| SCHEMBL31069853 | 0.77 | MAPT (0.72) | MAPTSMN1; SMN2CYP2C9CYP2C19TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441762-A1 | Potentiators of Glutamate Receptors | Eli Lilly and Company (US) | 2012-04-18 | — | — | EP | disclosed |