Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 16/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL17558458 | 0.86 | IGF1R (0.52) | IGF1RARTSHRKMT2A | |
| SCHEMBL6172123 | 0.84 | IGF1R (0.38) | IGF1RNTRK1AR | |
| Trifluoroacetic Acid SCHEMBL17558379 | 0.84 | IGF1R (0.42) | IGF1RNTRK1AR | |
| SCHEMBL17558435 | 0.83 | IGF1R (0.36) | IGF1RNTRK1AR | |
| SCHEMBL6175028 | 0.79 | IGF1R (0.45) | IGF1RNTRK1AR | |
| SCHEMBL6173427 | 0.79 | IGF1R (0.45) | IGF1RNTRK1AR | |
| Trifluoroacetic Acid SCHEMBL3727093 | 0.77 | IGF1R (0.47) | IGF1RNTRK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6175223 | 0.77 | IGF1R (0.43) | IGF1RNTRK1AR | |
| Trifluoroacetic Acid SCHEMBL2933617 | 0.75 | IGF1R (0.65) | IGF1R | |
| Trifluoroacetic Acid SCHEMBL17558384 | 0.74 | IGF1R (0.51) | IGF1RAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |