Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GPR6 | P46095 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL17558384 | 0.88 | IGF1R (0.51) | IGF1RARPTGDR2SYKNAMPT | |
| SCHEMBL6172757 | 0.87 | IGF1R (0.57) | IGF1RARPTGDR2TSHRKMT2A | |
| Trifluoroacetic Acid SCHEMBL17558363 | 0.87 | IGF1R (0.50) | IGF1RARPTGDR2CA1CA2 | |
| Trifluoroacetic Acid SCHEMBL17558337 | 0.86 | IGF1R (0.37) | IGF1RARTSHRKMT2A | |
| Trifluoroacetic Acid SCHEMBL17558350 | 0.84 | IGF1R (0.60) | IGF1RARPTGDR2KMT2ASYK | |
| Trifluoroacetic Acid SCHEMBL17558459 | 0.84 | IGF1R (0.60) | IGF1RARPTGDR2KMT2ASYK | |
| SCHEMBL17558392 | 0.83 | IGF1R (0.51) | IGF1RARSYKNAMPT | |
| SCHEMBL6173223 | 0.81 | IGF1R (0.55) | IGF1RARTSHRKMT2ANAMPT | |
| SCHEMBL6171503 | 0.79 | IGF1R (0.65) | IGF1RARPTGDR2TSHRKMT2A | |
| SCHEMBL6175292 | 0.79 | IGF1R (0.65) | IGF1RARPTGDR2TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |