Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 15/20 | 0.73 |
| ▸ | BRD1 | O95696 | 8/20 | 0.73 |
| ▸ | BRPF3 | Q9ULD4 | 6/20 | 0.73 |
| ▸ | BRD4 | O60885 | 5/20 | 0.73 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.73 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.71 |
| ▸ | KDM1A | O60341 | 1/20 | 0.59 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | EEF2K | O00418 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17560651 | 0.87 | BRPF1 (0.63) | BRPF1BRD1BRPF3BRD4BRD9 | |
| SCHEMBL17576473 | 0.85 | BRPF1 (1.00) | BRPF1BRD1BRPF3BRD4BRD9 | |
| SCHEMBL17560658 | 0.85 | BRPF1 (0.69) | BRPF1BRD1BRPF3BRD4BRD9 | |
| SCHEMBL17560675 | 0.83 | BRPF1 (0.67) | BRPF1BRD1BRPF3BRD4BRD9 | |
| SCHEMBL17560671 | 0.82 | BRPF1 (0.77) | BRPF1BRD1BRPF3BRD4BRD9 | |
| SCHEMBL17560661 | 0.78 | BRPF1 (0.80) | BRPF1BRD1BRPF3BRD4BRD9 | |
| SCHEMBL14721985 | 0.77 | BRPF1 (1.00) | BRPF1BRD1BRPF3BRD4BRD9 | |
| SCHEMBL17560722 | 0.76 | BRPF1 (0.79) | BRPF1BRD1BRPF3BRD4BRD9 | |
| SCHEMBL14722196 | 0.74 | BRPF1 (1.00) | BRPF1BRD1BRPF3BRD4BRD9 | |
| SCHEMBL12903520 | 0.74 | PKM (0.68) | CDC7EEF2KPLK4AURKADYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170291875-A1 | QUINOLONES AS INHIBITORS OF CLASS IV BROMODOMAIN PROTEINS | UCL BUSINESS PLC (GB) | 2017-10-12 | — | — | US | disclosed |
| EP-3189037-A1 | QUINOLONES AS INHIBITORS OF CLASS IV BROMODOMAIN PROTEINS | UCL Business PLC (GB) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016034512-A1 | QUINOLONES AS INHIBITORS OF CLASS IV BROMODOMAIN PROTEINS | UCL BUSINESS PLC (GB) | 2016-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170291875-A1 | QUINOLONES AS INHIBITORS OF CLASS IV BROMODOMAIN PROTEINS | BRD4, BRPF3, BRD3 | BRPF1 104/4885BRD1 4/4885BRPF3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.