SCHEMBL17560976

SCHEMBL17560976

Cc1ccccc1C(=O)Nc1cc(C(=O)Nc2c(Cl)cc(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)cc2Cl)ccc1C#N

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
HPGD P15428 1/20 0.43
MAPT P10636 1/20 0.41
RXFP1 Q9HBX9 3/20 0.39
TP53 P04637 1/20 0.38
THRB P10828 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
KCNMA1 Q12791 1/20 0.38
GAA P10253 2/20 0.38
LMNA P02545 2/20 0.38
KDM4E B2RXH2 1/20 0.38
PPARG P37231 2/20 0.38
NR1H4 Q96RI1 2/20 0.38
DHODH Q02127 1/20 0.37
KCNJ11 Q14654 1/20 0.37
TDP1 Q9NUW8 1/20 0.36
CYP2C9 P11712 1/20 0.36
BRAF P15056 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29360734 0.90 KMT2A (0.39) ALDH1A1MEN1KMT2AHPGDMAPT
SCHEMBL3703139 0.90 KMT2A (0.39) ALDH1A1MEN1KMT2AHPGDMAPT
SCHEMBL31375429 0.90 RXFP1 (0.39) ALDH1A1MEN1KMT2AHPGDMAPT
SCHEMBL29362569 0.87 KMT2A (0.38) ALDH1A1MEN1KMT2AHPGDMAPT
SCHEMBL3700196 0.87 KMT2A (0.38) ALDH1A1MEN1KMT2AHPGDMAPT
SCHEMBL12437616 0.86 ALDH1A1 (0.46) ALDH1A1MEN1KMT2AHPGDMAPT
SCHEMBL298875 0.86 KMT2A (0.40) ALDH1A1MEN1KMT2AHPGDMAPT
SCHEMBL29360338 0.86 KMT2A (0.40) ALDH1A1MEN1KMT2AHPGDMAPT
SCHEMBL29362173 0.85 KMT2A (0.36) ALDH1A1MEN1KMT2AHPGDMAPT
SCHEMBL3699644 0.85 KMT2A (0.36) ALDH1A1MEN1KMT2AHPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019175713-A1 NEW CATECHOL MOLECULES AND THEIR USE AS INHIBITORS TO P450 RELATED METABOLIC PATHWAYS BASF CORPORATION (US) 2019-09-19 WO claimed
WO-2016034353-A1 PESTICIDALLY ACTIVE MIXTURES BASF SE (DE) 2016-03-10 WO disclosed