Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12877767 | 0.76 | LMNA (0.64) | MAPTTBXAS1RECQLNPSR1KMT2A | |
| SCHEMBL13728276 | 0.75 | MAPT (0.56) | MAPTTBXAS1RECQLKAT2BNPSR1 | |
| SCHEMBL13829800 | 0.75 | MAPT (0.60) | MAPTTBXAS1RECQLKAT2BNPSR1 | |
| SCHEMBL13413651 | 0.72 | MAPT (0.54) | MAPTTBXAS1RECQLKAT2BALOX15 | |
| SCHEMBL3317990 | 0.71 | RECQL (0.55) | MAPTTBXAS1RECQLKAT2BNPSR1 | |
| SCHEMBL12877226 | 0.70 | MAPT (0.58) | MAPTRECQLALOX15ALDH1A1KMT2A | |
| SCHEMBL12877772 | 0.70 | TSHR (0.71) | MAPTRECQLALOX15ALDH1A1KMT2A | |
| SCHEMBL6890822 | 0.69 | MAPT (1.00) | MAPTRECQLALOX15ALDH1A1KMT2A | |
| SCHEMBL10421950 | 0.68 | MAPT (0.56) | MAPTTBXAS1RECQLNPSR1ALOX15 | |
| SCHEMBL18967143 | 0.67 | KMT2A (0.39) | MAPTNPSR1ALDH1A1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016036954-A1 | PHTHALAZINE DERIVATIVES OF FORMULA (I) AS PCAF AND GCN5 INHIBITORS FOR USE IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2016-03-10 | — | — | WO | disclosed |