Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.45 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17559376 | 0.99 | GPR119 (0.47) | GPR119S1PR1KMO | |
| SCHEMBL17559481 | 0.90 | GPR119 (0.48) | GPR119S1PR1 | |
| Lithium Ion SCHEMBL17559375 | 0.88 | GPR119 (0.47) | GPR119S1PR1 | |
| SCHEMBL17559337 | 0.85 | GPR119 (0.49) | GPR119S1PR1 | |
| SCHEMBL17559414 | 0.79 | PRMT5 (0.46) | GPR119 | |
| SCHEMBL2775980 | 0.78 | S1PR1 (0.61) | S1PR1KMO | |
| SCHEMBL17572982 | 0.76 | NOS3 (0.51) | GPR119 | |
| SCHEMBL17559447 | 0.75 | HRH3 (0.50) | GPR119 | |
| SCHEMBL19473336 | 0.73 | TLR8 (0.46) | GPR119 | |
| SCHEMBL289843 | 0.72 | EGFR (0.41) | GPR119S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170298075-A1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY. LTD. (AU) | 2017-10-19 | — | — | US | disclosed |
| WO-2016034673-A1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2016-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298075-A1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | PRMT5, PRMT1, PRMT3 | GPR119 3993/4885S1PR1 3847/4885KMO 1153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.