SCHEMBL17577136

SCHEMBL17577136

C=C(C)C(=O)OCCCc1ccc(-c2cc(-c3ccc(COC(=O)C(=C)C)cc3)c3ccc4cc(C(C)(C)C)cc5ccc2c3c54)cc1

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
RXRA P19793 1/20 0.33
RXRB P28702 1/20 0.33
RXRG P48443 1/20 0.33
POLB P06746 1/20 0.31
APEX1 P27695 1/20 0.31
HTT P42858 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
TSHR P16473 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17578282 0.90 RXRA (0.31) RXRARXRBRXRGPOLBAPEX1
SCHEMBL17577123 0.85 THRB (0.35) RXRARXRBRXRGTSHR
SCHEMBL17577137 0.82 THRB (0.36) RXRARXRBRXRGTSHR
SCHEMBL17577168 0.82 TSHR (0.49) POLBAPEX1HTTTDP1TSHR
SCHEMBL17578352 0.80 POLB (0.38) POLBAPEX1HTTTDP1
SCHEMBL17577212 0.80 POLB (0.38) POLBAPEX1HTTTDP1
SCHEMBL17577133 0.80 POLB (0.36) POLBAPEX1HTTTDP1TSHR
SCHEMBL17577169 0.80 TSHR (0.42) TSHR
SCHEMBL17427224 0.79
SCHEMBL19261018 0.79

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9594318-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2017-03-14 US disclosed
US-20160070184-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2016-03-10 US disclosed