Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | NR5A1 | Q13285 | 5/20 | 0.39 |
| ▸ | RORA | P35398 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576491 | 0.84 | PARP1 (0.58) | HTR2AHTR2CKDM4EPARP1NR5A1 | |
| SCHEMBL18378931 | 0.83 | HTR2A (0.48) | HTR2AHTR2CKDM4EPARP1CYP1A2 | |
| SCHEMBL1591139 | 0.80 | PARP1 (0.53) | PARP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL8959700 | 0.80 | HTR2C (0.71) | HTR2AHTR2CKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8959689 | 0.80 | HTR2C (0.71) | HTR2AHTR2CKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL15801423 | 0.79 | MAPT (0.48) | HTR2AHTR2CKDM4EPARP1CYP1A2 | |
| SCHEMBL1591452 | 0.79 | PARP1 (0.44) | PARP1TSHRHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL1590322 | 0.79 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL12668514 | 0.78 | PARP1 (0.48) | KDM4EPARP1CYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL1590424 | 0.77 | PARP1 (0.43) | KDM4EPARP1ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933622-B1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | SECOND GENOME INC (US) | 2016-03-09 | — | — | EP | disclosed |