Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.71 |
| ▸ | HTR2A | P28223 | 4/20 | 0.71 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959689 | 1.00 | HTR2C (0.71) | HTR2CHTR2APRMT5KDM4EP2RX7 | |
| SCHEMBL3251727 | 0.83 | HTR2C (0.56) | HTR2CHTR2APRMT5KDM4EASH1L | |
| SCHEMBL8959941 | 0.83 | HTR2C (1.00) | HTR2CHTR2APRMT5P2RX7 | |
| SCHEMBL8959931 | 0.83 | HTR2C (1.00) | HTR2CHTR2APRMT5P2RX7 | |
| SCHEMBL9234276 | 0.83 | HTR2C (1.00) | HTR2CHTR2APRMT5P2RX7 | |
| SCHEMBL8889300 | 0.80 | HTR2C (0.47) | HTR2CHTR2APRMT5KDM4EASH1L | |
| SCHEMBL17577751 | 0.80 | HTR2A (0.50) | HTR2CHTR2APRMT5KDM4EMAPT | |
| SCHEMBL8330041 | 0.79 | HTR2C (0.45) | HTR2CHTR2APRMT5KDM4EASH1L | |
| SCHEMBL27352015 | 0.78 | PRMT5 (0.54) | HTR2CHTR2APRMT5KDM4EASH1L | |
| SCHEMBL2120779 | 0.77 | HTR2C (0.62) | HTR2CHTR2APRMT5P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |