Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | NCF1 | P14598 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17579037 | 0.84 | MAPT (0.50) | HTTMAPTMAPK1AHRMET | |
| SCHEMBL17578998 | 0.81 | MET (0.49) | HTTMAPTMAPK1AHRMET | |
| SCHEMBL1543989 | 0.79 | NCF1 (0.70) | HTTMAPTMAPK1AHRMET | |
| SCHEMBL28089048 | 0.77 | HTT (0.49) | HTTMAPTMAPK1AHRNCF1 | |
| SCHEMBL17579060 | 0.76 | MET (0.53) | HTTMAPTMAPK1AHRMET | |
| SCHEMBL28089051 | 0.74 | MAPT (0.51) | HTTMAPTMAPK1AHRNPC1 | |
| SCHEMBL21865079 | 0.73 | SMN1; SMN2 (0.49) | HTTMAPTMAPK1AHRNPC1 | |
| SCHEMBL21865072 | 0.73 | BACE1 (0.43) | MAPTMAPK1NPC1HPGDRAB9A | |
| SCHEMBL3117120 | 0.73 | HTT (0.70) | HTTMAPTMAPK1AHRNPC1 | |
| SCHEMBL25666124 | 0.73 | RXFP1 (0.43) | HTTMAPTMAPK1AHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2995618-B1 | [1,2,4]TRIAZOL [4,3-A]PYRIDINE DERIVATE, PREPARATION METHOD THEREFOR OR MEDICAL APPLICATION THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN) | 2019-01-09 | — | — | EP | disclosed |
| EP-2995618-B1 | [1,2,4]TRIAZOL [4,3-A]PYRIDINE DERIVATE, PREPARATION METHOD THEREFOR OR MEDICAL APPLICATION THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN) | 2019-01-09 | — | — | EP | disclosed |
| US-9512121-B2 | [1,2,4] triazol [4,3-A] pyridine derivative, preparation method therefor or medical application thereof | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2016-12-06 | — | — | US | disclosed |
| US-9512121-B2 | [1,2,4] triazol [4,3-A] pyridine derivative, preparation method therefor or medical application thereof | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2016-12-06 | — | — | US | disclosed |
| US-9512121-B2 | [1,2,4] triazol [4,3-A] pyridine derivative, preparation method therefor or medical application thereof | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2016-12-06 | — | — | US | disclosed |
| US-20160122339-A1 | [1,2,4] TRIAZOL [4,3-A] PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR OR MEDICAL APPLICATION THEREOF | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2016-05-05 | — | — | US | disclosed |
| US-20160122339-A1 | [1,2,4] TRIAZOL [4,3-A] PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR OR MEDICAL APPLICATION THEREOF | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2016-05-05 | — | — | US | disclosed |
| US-20160122339-A1 | [1,2,4] TRIAZOL [4,3-A] PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR OR MEDICAL APPLICATION THEREOF | JIANGSU HANSOH PHARMACEUTICAL CO., LTD. (CN) | 2016-05-05 | — | — | US | disclosed |
| EP-2995618-A1 | [1,2,4]TRIAZOL [4,3-A]PYRIDINE DERIVATE, PREPARATION METHOD THEREFOR OR MEDICAL APPLICATION THEREOF | Jiangsu Hansoh Pharmaceutical Co., Ltd. (CN) | 2016-03-16 | — | — | EP | disclosed |
| EP-2995618-A1 | [1,2,4]TRIAZOL [4,3-A]PYRIDINE DERIVATE, PREPARATION METHOD THEREFOR OR MEDICAL APPLICATION THEREOF | Jiangsu Hansoh Pharmaceutical Co., Ltd. (CN) | 2016-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122339-A1 | [1,2,4] TRIAZOL [4,3-A] PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR OR MEDICAL APPLICATION THEREOF | MET, CYP4F11, WEE1 | HTT 4693/4885MAPT 3694/4885MAPK1 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.