Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203559 | 0.85 | ALDH1A1 (0.56) | HTTOR51E2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL17580571 | 0.79 | P2RX3 (0.41) | HTTALDH1A1HPGDSMN1; SMN2LPAR1 | |
| SCHEMBL22048697 | 0.79 | OR51E2 (0.43) | HTTOR51E2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL899151 | 0.76 | ALDH1A1 (0.71) | ALDH1A1MAPTCYP1A1CYP1A2CYP1B1 | |
| SCHEMBL5597294 | 0.75 | GAA (0.53) | HTTOR51E2ALDH1A1MAPTCYP1A1 | |
| SCHEMBL1758614 | 0.75 | ALDH1A1 (0.56) | HTTOR51E2ALDH1A1MAPTHPGD | |
| SCHEMBL543548 | 0.75 | TSHR (0.56) | HTTALDH1A1MAPTCYP1A2NPC1 | |
| SCHEMBL23190912 | 0.74 | CA12 (0.48) | HTTALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL31432473 | 0.73 | TRIM24 (0.56) | OR51E2ALDH1A1MAPTCYP1A1CYP1A2 | |
| SCHEMBL2095308 | 0.73 | OR51E2 (0.48) | HTTOR51E2ALDH1A1MAPTCYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834248-B1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |