Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15283283 | 0.90 | EGFR (0.42) | HTR6MAPTALDH1A1TDP1RAD52 | |
| SCHEMBL17580638 | 0.85 | LMNA (0.42) | MAPTALDH1A1TDP1RAD52SIRT6 | |
| SCHEMBL29226317 | 0.81 | PLK1 (0.48) | HTR6MAPT | |
| SCHEMBL30825044 | 0.81 | PLK1 (0.48) | HTR6MAPT | |
| SCHEMBL15283314 | 0.79 | ALK (0.42) | HTR6MAPTALDH1A1TDP1RAD52 | |
| SCHEMBL30132248 | 0.77 | SIRT6 (0.54) | HTR6ALDH1A1RAD52NPC1POLB | |
| SCHEMBL15283462 | 0.77 | SIRT6 (0.54) | HTR6ALDH1A1RAD52NPC1POLB | |
| SCHEMBL17580473 | 0.77 | GAA (0.41) | HTR6MAPTRAD52CCR5POLB | |
| SCHEMBL25699466 | 0.76 | MAPT (0.49) | HTR6MAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL15283363 | 0.75 | MAPT (0.54) | HTR6MAPTALDH1A1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834248-B1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |