Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15283283 | 0.84 | EGFR (0.42) | MAPTSIRT6DCLK1ALKHTR6 | |
| SCHEMBL12718983 | 0.84 | SIRT6 (0.56) | MAPTSIRT6ALKHTR6MAPK1 | |
| SCHEMBL16001227 | 0.81 | SIRT6 (0.46) | MAPTSIRT6HTR3AHTR6GAA | |
| SCHEMBL17580638 | 0.80 | LMNA (0.42) | MAPTSIRT6DCLK1ALKINSR | |
| SCHEMBL15283334 | 0.79 | GAA (0.58) | MAPTSIRT6HTR3AHTR6GAA | |
| SCHEMBL18210772 | 0.79 | HTR6 (0.46) | MAPTSIRT6HTR3AHTR6GAA | |
| SCHEMBL14180560 | 0.79 | SIRT6 (0.51) | MAPTSIRT6ALKHTR6INSR | |
| SCHEMBL16003359 | 0.79 | MAPT (0.48) | MAPTSIRT6HTR3AALKHTR6 | |
| SCHEMBL16001188 | 0.77 | SIRT6 (0.43) | MAPTSIRT6HTR3AHTR6GAA | |
| SCHEMBL15283363 | 0.77 | MAPT (0.54) | MAPTSIRT6HTR3AHTR6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023121207-A1 | PHARMACEUTICAL COMPOSITION, WHICH INHIBITS AAK1, FOR PREVENTING OR TREATING VIRAL DISEASES OR BRAIN DISEASES | 재단법인 대구경북첨단의료산업진흥재단 | 2023-06-29 | — | — | WO | disclosed |