Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | USP9X | Q93008 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17580677 | 0.95 | HTR6 (0.41) | HTR6HTR2AGRM5CHRM1ALK | |
| SCHEMBL17580741 | 0.91 | HTR6 (0.43) | HTR6HTR2AGRM5CHRM1ALK | |
| SCHEMBL17580996 | 0.91 | HTR6 (0.43) | HTR6HTR2AGRM5CHRM1ALK | |
| SCHEMBL17580761 | 0.90 | HTR6 (0.37) | HTR6USP9X | |
| SCHEMBL17580765 | 0.89 | TRPV1 (0.39) | HTR6USP9X | |
| SCHEMBL17580617 | 0.87 | HTR6 (0.42) | HTR6HTR2AGRM5CHRM1ALK | |
| SCHEMBL17580927 | 0.86 | HTR6 (0.46) | HTR6HTR2AGRM5CHRM1ALK | |
| SCHEMBL17580888 | 0.84 | HTR6 (0.52) | HTR6HTR2AGRM5CHRM1ALK | |
| SCHEMBL17580675 | 0.84 | HTR6 (0.44) | HTR6HTR2AGRM5CHRM1ALK | |
| SCHEMBL13359004 | 0.83 | HTR6 (0.61) | HTR6HTR2ACHRM1HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185555-B1 | QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | ABBVIE DEUTSCHLAND (DE) | 2016-03-16 | — | — | EP | claimed |