Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | USP9X | Q93008 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17580720 | 0.89 | HTR6 (0.42) | HTR6USP9X | |
| SCHEMBL17580798 | 0.88 | HTR6 (0.44) | TRPV1PIK3CAHTR6AKR1C3KDM4E | |
| SCHEMBL17580665 | 0.87 | PIK3CA (0.42) | TRPV1PIK3CAHTR6KDM4EHTT | |
| SCHEMBL17580761 | 0.84 | HTR6 (0.37) | PIK3CAHTR6USP9XTP53MAPT | |
| SCHEMBL17580677 | 0.83 | HTR6 (0.41) | HTR6 | |
| SCHEMBL3646672 | 0.83 | HTR6 (0.50) | SCN9APIK3CAHTR6AKR1C3KDM4E | |
| SCHEMBL9903397 | 0.82 | HTR6 (0.41) | TRPV1SCN9APIK3CAHTR6KDM4E | |
| SCHEMBL17580996 | 0.79 | HTR6 (0.43) | HTR6 | |
| SCHEMBL17580741 | 0.79 | HTR6 (0.43) | HTR6 | |
| SCHEMBL17580828 | 0.78 | CHRNB2 (0.45) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185555-B1 | QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | ABBVIE DEUTSCHLAND (DE) | 2016-03-16 | — | — | EP | claimed |