Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MIF | P14174 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11325775 | 0.89 | CYP1A2 (0.59) | HPGDCYP1A2F3ALDH1A1HTT | |
| SCHEMBL8883177 | 0.89 | CYP1A2 (0.59) | HPGDCYP1A2F3ALDH1A1HTT | |
| SCHEMBL5754478 | 0.79 | CYP1A2 (0.61) | HPGDCYP1A2F3ALDH1A1HTT | |
| SCHEMBL5754475 | 0.79 | CYP1A2 (0.61) | HPGDCYP1A2F3ALDH1A1HTT | |
| SCHEMBL9427450 | 0.75 | ALDH1A1 (0.62) | HPGDCYP1A2F3ALDH1A1HTT | |
| SCHEMBL11503007 | 0.75 | HPGD (0.56) | HPGDCYP1A2ALDH1A1PIM1PIM3 | |
| SCHEMBL11503006 | 0.75 | HPGD (0.56) | HPGDCYP1A2ALDH1A1PIM1PIM3 | |
| SCHEMBL6851578 | 0.74 | CYP1A2 (0.64) | HPGDCYP1A2F3ALDH1A1HTT | |
| SCHEMBL21539509 | 0.74 | CYP1A2 (0.64) | HPGDCYP1A2F3ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL31432924 | 0.72 | HPGD (0.53) | HPGDCYP1A2F3ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994135-B1 | NOVEL BIS-BENZYLIDINE PIPERIDINONE PROTEASOME INHIBITOR WITH ANTICANCER ACTIVITY | UNIV JOHNS HOPKINS (US) | 2021-10-06 | — | — | EP | disclosed |
| US-20190175572-A1 | NOVEL-BIS-BENZYLIDINE PIPERIDONE PROTEASOME INHIBITOR WITH ANTICANCER ACTIVITY | THE JOHNS HOPKINS UNIVERSITY (US) | 2019-06-13 | — | — | US | disclosed |
| US-9913834-B2 | Bis-benzylidine piperidone proteasome inhibitor with anticancer activity | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-03-13 | — | — | US | disclosed |
| US-20160106725-A1 | Novel bis-Benzylidine Piperidone Proteasome Inhibitor with Anticancer Activity | THE JOHNS HOPKINS UNIVERSITY | 2016-04-21 | — | — | US | disclosed |
| EP-2994135-A1 | NOVEL BIS-BENZYLIDINE PIPERIDONE PROTEASOME INHIBITOR WITH ANTICANCER ACTIVITY | The Johns Hopkins University (US) | 2016-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190175572-A1 | NOVEL-BIS-BENZYLIDINE PIPERIDONE PROTEASOME INHIBITOR WITH ANTICANCER ACTIVITY | ADRM1, PSMC1, PSMD13 | HPGD 3888/4885CYP1A2 2621/4885F3 4733/4885 |
| US-20160106725-A1 | Novel bis-Benzylidine Piperidone Proteasome Inhibitor with Anticancer Activity | ADRM1, PSMC1, PSMB3 | HPGD 3857/4885CYP1A2 2454/4885F3 4718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.