Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | GFER | P55789 | 2/20 | 0.57 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.53 |
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1757734 | 0.83 | LMNA (0.69) | LMNAEIF2AK2HTR6HTR7MAPT | |
| SCHEMBL1758180 | 0.83 | LMNA (0.69) | LMNAMEN1KMT2AGFEREIF2AK2 | |
| SCHEMBL1757597 | 0.81 | LMNA (0.66) | LMNAMEN1KMT2AGFEREIF2AK2 | |
| SCHEMBL1758455 | 0.77 | LMNA (1.00) | LMNAMEN1KMT2AEIF2AK2HTR6 | |
| SCHEMBL31105763 | 0.77 | EIF2AK2 (0.68) | MEN1KMT2AGFEREIF2AK2HTR6 | |
| SCHEMBL1757976 | 0.73 | MEN1 (0.49) | LMNAMEN1KMT2AGFEREIF2AK2 | |
| SCHEMBL27145307 | 0.73 | MEN1 (1.00) | MEN1KMT2AGFEREIF2AK2HTR6 | |
| SCHEMBL30693718 | 0.73 | MEN1 (1.00) | MEN1KMT2AGFEREIF2AK2HTR6 | |
| SCHEMBL18019742 | 0.72 | ALDH1A1 (0.57) | MEN1KMT2AGFERHTR6HTR7 | |
| SCHEMBL1720491 | 0.71 | MEN1 (0.57) | MEN1KMT2AGFEREIF2AK2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105509-A1 | INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS | WYETH, LLC (US) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105509-A1 | INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS | HRH2, CRHR2, CRHR1 | LMNA 4342/4885MEN1 3026/4885KMT2A 3787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.