Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.63 |
| ▸ | LDHA | P00338 | 1/20 | 0.55 |
| ▸ | HPGDS | O60760 | 1/20 | 0.52 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.51 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.51 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.51 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | SCN4A | P35499 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758258 | 0.86 | LDHA (0.69) | LDHAHPGDSALDH1A1RXFP1CHEK2 | |
| SCHEMBL29586559 | 0.86 | LDHA (0.73) | LDHAHPGDSALDH1A1RXFP1CHEK2 | |
| SCHEMBL1246554 | 0.86 | LDHA (0.73) | LDHAHPGDSALDH1A1RXFP1CHEK2 | |
| Hydrochloric Acid SCHEMBL5010814 | 0.84 | LDHA (0.71) | LDHAHPGDSALDH1A1RXFP1CHEK2 | |
| SCHEMBL27993361 | 0.83 | PARP10 (0.64) | PARP10PARP15PARP14ALDH1A1KMT2A | |
| SCHEMBL29596790 | 0.83 | RXFP1 (0.56) | LDHAHPGDSALDH1A1KMT2ARXFP1 | |
| SCHEMBL1758177 | 0.82 | RXFP1 (0.75) | PARP10HPGDSPARP4RXFP1CHEK2 | |
| SCHEMBL1758392 | 0.79 | PARP10 (0.66) | PARP10HPGDSALDH1A1KMT2ARXFP1 | |
| SCHEMBL606429 | 0.79 | PARP10 (1.00) | PARP10PARP15PARP14ALDH1A1KMT2A | |
| Terephthalamide SCHEMBL4205368 | 0.79 | PARP10 (1.00) | PARP10PARP15PARP14ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105549-B2 | Aryl substituted pyridines and the use thereof | EURO-CELTIQUE S.A. (LU) | 2006-09-12 | — | — | US | claimed |
| EP-1432419-A1 | ARYL SUBSTITUTED PYRIDINECARBOXAMIDES AND THEIR USE AS SODIUM CHANNEL BLOCKERS | Euro-Celtique S.A. (LU) | 2004-06-30 | — | — | EP | claimed |
| US-20030055088-A1 | Aryl substituted pyridines and the use thereof | EURO-CELTIQUE S.A. | 2003-03-20 | — | — | US | claimed |
| WO-2003022276-A1 | ARYL SUBSTITUTED PYRIDINECARBOXAMIDES AND THEIR USE AS SODIUM CHANNEL BLOCKERS | EURO-CELTIQUE S.A. (LU) | 2003-03-20 | — | — | WO | claimed |
| CN-107226805-A | Aromatic amides analog derivative, its preparation method and its in application pharmaceutically | 北京天诚医药科技有限公司 | 2017-10-03 | — | — | CN | disclosed |
| CN-104341388-A | Aromatic amide derivative as well as preparation method and medicinal application thereof | SHANGHAI RUNNUO BIOTECHNOLOGY CO LTD | 2015-02-11 | — | — | CN | disclosed |
| US-7943643-B2 | Aryl substituted pyridines and the use thereof | PURDUE PHARMA L.P. (US) | 2011-05-17 | — | — | US | disclosed |
| US-20100048626-A1 | Aryl Substituted Pyridines and the Use Thereof | PURDUE PHARMA L.P. | 2010-02-25 | — | — | US | disclosed |
| US-7579367-B2 | Aryl substituted pyridines and the use thereof | PURDUE PHARMA L.P. (US) | 2009-08-25 | — | — | US | disclosed |
| US-20080194627-A9 | Aryl substituted pyridines and the use thereof | EURO-CELTIQUE S.A. (LU) | 2008-08-14 | — | — | US | disclosed |
| US-20070010554-A1 | Aryl substituted pyridines and the use thereof | EURO-CELTIQUE S.A. (LU) | 2007-01-11 | — | — | US | disclosed |
| US-7105549-B2 | Aryl substituted pyridines and the use thereof | EURO-CELTIQUE S.A. (LU) | 2006-09-12 | — | — | US | disclosed |
| EP-1432419-A1 | ARYL SUBSTITUTED PYRIDINECARBOXAMIDES AND THEIR USE AS SODIUM CHANNEL BLOCKERS | Euro-Celtique S.A. (LU) | 2004-06-30 | — | — | EP | disclosed |
| US-20030055088-A1 | Aryl substituted pyridines and the use thereof | EURO-CELTIQUE S.A. | 2003-03-20 | — | — | US | disclosed |
| WO-2003022276-A1 | ARYL SUBSTITUTED PYRIDINECARBOXAMIDES AND THEIR USE AS SODIUM CHANNEL BLOCKERS | EURO-CELTIQUE S.A. (LU) | 2003-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194627-A9 | Aryl substituted pyridines and the use thereof | CACNA1S, CACNA1E, CACNA1C | PARP10 2411/4885LDHA 162/4885HPGDS 3962/4885 |
| US-20100048626-A1 | Aryl Substituted Pyridines and the Use Thereof | CACNA1S, CACNA1E, CACNA1C | PARP10 2285/4885LDHA 194/4885HPGDS 4009/4885 |
| US-20030055088-A1 | Aryl substituted pyridines and the use thereof | CACNA1S, CACNA1E, CACNA1D | PARP10 3325/4885LDHA 164/4885HPGDS 3747/4885 |
| US-20070010554-A1 | Aryl substituted pyridines and the use thereof | CACNA1S, CACNA1E, CACNA1C | PARP10 2411/4885LDHA 162/4885HPGDS 3962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.