Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 6/20 | 0.41 |
| ▸ | IP6K3 | Q96PC2 | 3/20 | 0.41 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 7/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17586156 | 0.83 | IP6K1 (0.41) | IP6K1IP6K3IP6K2PARP1PDPK1 | |
| SCHEMBL17586164 | 0.81 | IP6K1 (0.42) | IP6K1IP6K3IP6K2PARP1PDPK1 | |
| SCHEMBL17586166 | 0.78 | IP6K1 (0.39) | IP6K1IP6K3IP6K2PARP1PDPK1 | |
| SCHEMBL17586151 | 0.73 | IP6K1 (0.46) | IP6K1IP6K3IP6K2PARP1PDPK1 | |
| SCHEMBL17586181 | 0.73 | IP6K1 (0.58) | IP6K1IP6K3IP6K2PARP1PDPK1 | |
| SCHEMBL17586167 | 0.69 | ALDH1A1 (0.56) | IP6K1IP6K3IP6K2PARP1SMN1; SMN2 | |
| SCHEMBL9199094 | 0.69 | PARP1 (0.56) | IP6K1IP6K3IP6K2PARP1PDPK1 | |
| SCHEMBL17586185 | 0.68 | IP6K1 (0.52) | IP6K1IP6K3IP6K2PARP1PDPK1 | |
| SCHEMBL17586152 | 0.68 | PARP1 (0.70) | IP6K1IP6K3IP6K2PARP1CHEK1 | |
| SCHEMBL17586159 | 0.68 | IP6K1 (0.46) | IP6K1IP6K3IP6K2PARP1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493426-B2 | Quinazolinone derivatives useful as FGFR kinase modulators | ASTEX THERAPEUTICS LIMITED (GB) | 2016-11-15 | — | — | US | disclosed |
| US-20160075666-A1 | QUINAZOLINONE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2016-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075666-A1 | QUINAZOLINONE DERIVATIVES USEFUL AS FGFR KINASE MODULATORS | FGFR1, FGFR3, FGFR2 | IP6K1 471/4885IP6K3 443/4885IP6K2 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.