Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | ESRRB | O95718 | 1/20 | 0.46 |
| ▸ | ESRRA | P11474 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534510 | 0.83 | MAPK1 (0.55) | MAPK1ESR1ESR2AURKAAURKB | |
| SCHEMBL4559016 | 0.83 | ACHE (0.61) | ESR1ESR2ESRRBESRRASMN1; SMN2 | |
| SCHEMBL401224 | 0.81 | POLB (0.60) | MAPK1ESR1ESR2AURKAAURKB | |
| SCHEMBL1758867 | 0.81 | MAPK1 (0.52) | MAPK1ESR1ESR2AURKAAURKB | |
| SCHEMBL16098232 | 0.78 | MAPK1 (0.54) | MAPK1ESR1ESR2AURKAAURKB | |
| SCHEMBL1901263 | 0.77 | KDM4E (0.72) | ALDH1A1SMN1; SMN2HPGDPTGESALOX5 | |
| SCHEMBL16099274 | 0.77 | MAPK1 (0.52) | MAPK1ESR1ESR2AURKAAURKB | |
| SCHEMBL402385 | 0.77 | ACHE (0.53) | MAPK1ESR1ESR2AURKAAURKB | |
| SCHEMBL26203101 | 0.77 | MAPK1 (0.81) | MAPK1ESR1ESR2AURKAAURKB | |
| SCHEMBL26203095 | 0.76 | MAPK1 (0.58) | MAPK1ESR1ESR2AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120220595-A1 | Deuterated Tyrosine Kinase Inhibitors | OSI Pharmaceuticals, LLC | 2012-08-30 | — | — | US | disclosed |
| US-20120220595-A1 | Deuterated Tyrosine Kinase Inhibitors | OSI Pharmaceuticals, LLC | 2012-08-30 | — | — | US | disclosed |
| US-20120220595-A1 | Deuterated Tyrosine Kinase Inhibitors | OSI Pharmaceuticals, LLC | 2012-08-30 | — | — | US | disclosed |
| WO-2011060112-A1 | DEUTERATED TYROSINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011060112-A1 | DEUTERATED TYROSINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220595-A1 | Deuterated Tyrosine Kinase Inhibitors | IGF1R, INSR, IRS1 | MAPK1 41/4885ESR1 792/4885ESR2 1074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.