SCHEMBL4559016

SCHEMBL4559016

Brc1cc(-c2ccccc2)nc2ccccc12

nearest known ligand 0.61

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.61
LMNA P02545 3/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
KDM4E B2RXH2 2/20 0.56
HPGD P15428 2/20 0.56
PDE10A Q9Y233 1/20 0.56
ESRRB O95718 1/20 0.54
ESR1 P03372 1/20 0.54
ESRRA P11474 1/20 0.54
ESR2 Q92731 1/20 0.54
DHODH Q02127 1/20 0.53
ACACA Q13085 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
SLC2A1 P11166 1/20 0.49
CYP2C9 P11712 1/20 0.47
CYP3A4 P08684 1/20 0.47
TOP1 P11387 1/20 0.47
RXFP1 Q9HBX9 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7259981 0.90 ACHE (0.47) ACHELMNASMN1; SMN2KDM4EHPGD
SCHEMBL1758675 0.83 MAPK1 (0.52) ACHESMN1; SMN2KDM4EHPGDESRRB
SCHEMBL29399315 0.79 ACACA (0.72) ACHELMNASMN1; SMN2KDM4EHPGD
SCHEMBL1042853 0.79 ACACA (0.72) ACHELMNASMN1; SMN2KDM4EHPGD
SCHEMBL29400688 0.78 ACACA (0.65) ACHELMNASMN1; SMN2KDM4EHPGD
SCHEMBL28251703 0.78 ACACA (0.65) ACHELMNASMN1; SMN2KDM4EHPGD
SCHEMBL969768 0.78 ACACA (0.65) ACHELMNASMN1; SMN2KDM4EHPGD
SCHEMBL4594838 0.78 ACACA (0.75) ACHELMNASMN1; SMN2KDM4EHPGD
SCHEMBL16990162 0.78 ACACA (0.70) ACHELMNASMN1; SMN2KDM4EHPGD
SCHEMBL6631411 0.77 ACHE (0.58) ACHELMNASMN1; SMN2KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101280186-A Photophosphorescence material contain iridium complex of phenylquinoline and acidamide group and preparation thereof UNIV JIANGNAN (CN) 2008-10-08 CN claimed
US-11785844-B2 Organic light emitting device, method for manufacturing same and composition for organic material layer LT MATERIALS CO., LTD. (KR) 2023-10-10 US disclosed
US-11785844-B2 Organic light emitting device, method for manufacturing same and composition for organic material layer LT MATERIALS CO., LTD. (KR) 2023-10-10 US disclosed
CN-115521253-B Bibiquinoline derivative compound and application thereof 烟台显华科技集团股份有限公司 2023-04-07 CN disclosed
CN-115521253-A Bibiquinoline derivative compound and application thereof 烟台显华科技集团股份有限公司 2022-12-27 CN disclosed
US-11527723-B2 Heterocyclic compound and organic light emitting element comprising same LT MATERIALS CO., LTD. (KR) 2022-12-13 US disclosed
WO-2022239930-A1 HETEROCYCLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME, AND COMPOSITION FOR ORGANIC MATERIAL LAYER OF ORGANIC LIGHT-EMITTING DEVICE 엘티소재주식회사 2022-11-17 WO disclosed
US-11387418-B2 Organic light emitting element and composition for organic material layer in organic light emitting element LT MATERIALS CO., LTD. (KR) 2022-07-12 US disclosed
EP-3604298-B1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING ELEMENT COMPRISING SAME LT MATERIALS CO LTD (KR) 2022-03-30 EP disclosed
WO-2021235820-A1 ORGANIC LIGHT-EMITTING DEVICE 엘티소재주식회사 2021-11-25 WO disclosed
US-7632845-B2 2-(p-oxyphenyl)-6-oxyquinolines, e.g., 2-(3-Fluoro-4-hydroxyphenyl)-4-phenylquinolin-6-ol; inflammatory bowel disease; Crohn's disease; anticarcinogenic agents; anticholesterol agents; antilipemic agents; cardiovascular diorders; osteoporosis; A lzheimer's disease; fertility; antiarthritic agents WYETH (US) 2009-12-15 US disclosed
CN-101280186-A Photophosphorescence material contain iridium complex of phenylquinoline and acidamide group and preparation thereof UNIV JIANGNAN (CN) 2008-10-08 CN disclosed
US-20060217399-A1 Phenyl quinolines and their use as estrogenic agents WYETH (US) 2006-09-28 US disclosed
CN-1823046-A Phenyl quinolines and their use as estrogen receptor modulators WYETH CORP (US) 2006-08-23 CN disclosed
US-7084276-B2 Phenyl quinolines and their use as estrogenic agents WYETH (US) 2006-08-01 US disclosed
EP-1628961-A1 PHENYL QUINOLINES AND THEIR USE AS ESTROGEN RECEPTOR MODULATORS Wyeth (US) 2006-03-01 EP disclosed
US-20050009784-A1 Phenyl quinolines and their use as estrogenic agents WYETH 2005-01-13 US disclosed
WO-2004103973-A1 PHENYL QUINOLINES AND THEIR USE AS ESTROGEN RECEPTOR MODULATORS WYETH (US) 2004-12-02 WO disclosed
US-4788204-A TRANQUILIZERS; ANTICONVULSANTS; ANGINA AND IMMUNODIFICIENCY TREATMENTS RHONE-POULENC SANTE (FR) 1988-11-29 US disclosed
US-4788199-A ANXIOLYTICS, ANTICONVULSANTS, ANTIANGINA AGENTS RHONE-POULENC SANTE (FR) 1988-11-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11387418-B2 Organic light emitting element and composition for organic material layer in organic light emitting element CRY1, CYBA, L1CAM ACHE 978/4885LMNA 947/4885SMN1; SMN2 3849/4885
US-20050009784-A1 Phenyl quinolines and their use as estrogenic agents ESR1, GPER1, ESR2 ACHE 837/4885LMNA 3392/4885SMN1; SMN2 4647/4885
US-20060217399-A1 Phenyl quinolines and their use as estrogenic agents ESR1, GPER1, ESR2 ACHE 837/4885LMNA 3392/4885SMN1; SMN2 4647/4885
US-11527723-B2 Heterocyclic compound and organic light emitting element comprising same CRY1, CRY2, CYP1A1 ACHE 1269/4885LMNA 3451/4885SMN1; SMN2 3668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.