Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.57 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.57 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.57 |
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2804607 | 0.98 | CHRM1 (0.56) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Ammonia Solution, Strong SCHEMBL28330597 | 0.96 | CHRM1 (0.54) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL16637633 | 0.80 | CHRM5 (0.56) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL28878493 | 0.80 | CHRM1 (0.50) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL808458 | 0.78 | CHRM1 (0.54) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL3784397 | 0.77 | CHRM1 (0.48) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL7125777 | 0.77 | CHRM1 (0.54) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL28421705 | 0.76 | CHRM1 (0.46) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL2010713 | 0.75 | CES2 (0.37) | LMNACYP2C19TSHRBLMSMN1; SMN2 | |
| SCHEMBL2241590 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116617337-A | Compound Chinese herbal medicine for promoting ruminant and preparation method thereof | 武威牛满加药业有限责任公司 | 2023-08-22 | — | — | CN | claimed |
| CN-114053207-A | Sustained-release pharmaceutical composition and preparation method thereof | 常州恒邦药业有限公司 | 2022-02-18 | — | — | CN | disclosed |
| US-20190321346-A1 | COMBINATIONS OF ACETYLCHOLINESTERASE INHIBITORS AND MUSCARINIC AGONISTS AND METHODS OF USE THEREOF | GOLDFARB SIDNEY J (US) | 2019-10-24 | — | — | US | disclosed |
| US-10357487-B2 | Combinations of acetylcholinesterase inhibitors and muscarinic agonists and methods of use thereof | GOLDFARB SIDNEY J (US) | 2019-07-23 | — | — | US | disclosed |
| US-10137084-B2 | Use of bethanechol for treatment of xerostomia | ACACIA PHARMA LIMITED (GB) | 2018-11-27 | — | — | US | disclosed |
| CN-108048421-A | The method that transfructosylase catalytic efficiency and stability are improved using choline eutectic solvent | 天津科技大学 | 2018-05-18 | — | — | CN | disclosed |
| CN-105518183-B | The production of graphene and graphite alkane | 曼彻斯特大学 | 2018-03-27 | — | — | CN | disclosed |
| US-20170157100-A1 | Combinations of Acetylcholinesterase Inhibitors and Muscarinic Agonists and Methods of Use Thereof | GOLDFARB SIDNEY J (US) | 2017-06-08 | — | — | US | disclosed |
| US-9492546-B2 | Use of bethanechol for treatment of Xerostomia | ACACIA PHARMA LIMITED (GB) | 2016-11-15 | — | — | US | disclosed |
| US-20160287512-A1 | USE OF BETHANECHOL FOR TREATMENT OF XEROSTOMIA | ACACIA PHARMA LIMITED | 2016-10-06 | — | — | US | disclosed |
| US-20150366794-A1 | USE OF BETHANECHOL FOR TREATMENT OF XEROSTOMIA | ACACIA PHARMA LIMITED (GB) | 2015-12-24 | — | — | US | disclosed |
| US-9149454-B2 | Use of bethanechol for treatment of xerostomia | ACACIA PHARMA LIMITED (GB) | 2015-10-06 | — | — | US | disclosed |
| US-20140187629-A1 | Use of Bethanechol for Treatment of Xerostomia | ACACIA PHARMA LIMITED (GB) | 2014-07-03 | — | — | US | disclosed |
| EP-2704705-A1 | USE OF BETHANECHOL FOR TREATMENT OF XEROSTOMIA | Acacia Pharma Limited (GB) | 2014-03-12 | — | — | EP | disclosed |
| EP-2498771-B1 | USE OF BETHANECHOL FOR TREATMENT OF XEROSTOMIA | ACACIA PHARMA LTD (GB) | 2013-12-25 | — | — | EP | disclosed |
| WO-2012153110-A1 | USE OF BETHANECHOL FOR TREATMENT OF XEROSTOMIA | ACACIA PHARMA LIMITED (GB) | 2012-11-15 | — | — | WO | disclosed |
| EP-2498771-A1 | USE OF BETHANECHOL FOR TREATMENT OF XEROSTOMIA | Acacia Pharma Limited (GB) | 2012-09-19 | — | — | EP | disclosed |
| US-20120232137-A1 | Use of Bethaneciol for Treatment of Xerostomia | ACACIA PHARMA LIMITED | 2012-09-13 | — | — | US | disclosed |
| WO-2011058366-A1 | USE OF BETHANECHOL FOR TREATMENT OF XEROSTOMIA | ACACIA PHARMA LIMITED (GB) | 2011-05-19 | — | — | WO | disclosed |
| CN-1315856-A | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor | MEDINOX INC (US) | 2001-10-03 | — | — | CN | disclosed |