Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.56 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.56 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.52 |
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.52 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.52 |
| ▸ | GALR3 | O60755 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7125777 | 0.98 | CHRM1 (0.54) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL28878493 | 0.82 | CHRM1 (0.50) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL1759062 | 0.80 | CHRM5 (0.57) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL3784397 | 0.79 | CHRM1 (0.48) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Methacholine SCHEMBL15578379 | 0.78 | CHRM1 (0.64) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL28421705 | 0.77 | CHRM1 (0.46) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL2804607 | 0.77 | CHRM1 (0.56) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL366719 | 0.77 | CHRM5 (0.45) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL2269120 | 0.77 | ACHE (0.54) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL11065093 | 0.77 | CES2 (0.61) | CHRM5CHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110950767-B | Methacholine chloride crystal form and preparation method thereof | 北京泰德制药股份有限公司 | 2022-10-28 | — | — | CN | disclosed |
| CN-114487148-A | Method for detecting genotoxic impurities | 北京泰德制药股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-113368065-A | Formulation of freeze-dried powder of methacholine chloride for inhalation and preparation method thereof | 上海轩耘生物医药科技有限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-111635327-A | Amorphous crystal form of methacholine chloride and preparation method thereof | 北京磐谷英汇科技有限公司 | 2020-09-08 | — | — | CN | disclosed |
| CN-110950767-A | Novel crystal form of methacholine chloride and preparation method thereof | 北京泰德制药股份有限公司 | 2020-04-03 | — | — | CN | disclosed |
| CN-106962381-A | Plant growth regulator composition with synergistic effect | 江苏辉丰农化股份有限公司 | 2017-07-21 | — | — | CN | disclosed |
| CN-106212492-A | There is the plant growth regulator composition of potentiation | 江苏辉丰农化股份有限公司 | 2016-12-14 | — | — | CN | disclosed |
| WO-2015054253-A1 | METHODS AND COMPOSITIONS FOR GENE CORRECTION USING NUCLEOTIDE-MODIFIED MESSENGER RNA | SANGAMO BIOSCIENCES, INC. (US) | 2015-04-16 | — | — | WO | disclosed |
| CN-101195046-B | Bioabsorbable device having encapsulated additives for accelerating degradation | CORDIS CORP | 2014-03-05 | — | — | CN | disclosed |
| CN-101195046-A | Bioabsorbable device having encapsulated additives for accelerating degradation | CORDIS CORP (US) | 2008-06-11 | — | — | CN | disclosed |