Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31471473 | 0.74 | ACHE (0.69) | ACHEALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL29373699 | 0.74 | ACHE (0.69) | ACHEALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL301247 | 0.74 | ACHE (0.69) | ACHEALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL12279036 | 0.72 | HPGD (0.42) | ACHEL3MBTL1ALDH1A1HPGDKMT2A | |
| SCHEMBL11663415 | 0.72 | KMT2A (0.71) | L3MBTL1ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL18797759 | 0.71 | ACHE (0.65) | ACHEALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL19577801 | 0.71 | ACHE (0.65) | ACHEALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL10429722 | 0.71 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1KMT2ARAB9ANPC1 | |
| SCHEMBL25077726 | 0.71 | TLR8 (0.42) | ACHEALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL12279326 | 0.70 | KMT2A (0.38) | ACHEL3MBTL1KMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776430-B1 | 2- (1,2,3-TRIAZOL-2-YL) BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL) PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-03-16 | — | — | EP | disclosed |