Sugi Predict

Sugi Predict / Compounds / SCHEMBL17592111

SCHEMBL17592111

SCHEMBL17592111

Cc1ccncc1-c1cc2c(-c3nc4c(-c5cc(F)cc(OCCN6CCCC6)c5)ccnc4[nH]3)n[nH]c2cn1

nearest known ligand 0.59

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ WNT1 P04628 12/20 0.59
▸ CLK2 P49760 9/20 0.59
▸ DYRK1A Q13627 9/20 0.59
▸ CLK3 P49761 8/20 0.59
▸ TGFBR1 P36897 6/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19340195 0.92 WNT1 (0.63) WNT1CLK2DYRK1ACLK3TGFBR1
SCHEMBL17566941 0.92 WNT1 (0.71) WNT1CLK2DYRK1ACLK3TGFBR1
SCHEMBL17575864 0.92 CLK2 (0.67) WNT1CLK2DYRK1ACLK3TGFBR1
SCHEMBL17594386 0.92 WNT1 (0.58) WNT1CLK2DYRK1ACLK3TGFBR1
SCHEMBL17592827 0.91 WNT1 (0.61) WNT1CLK2DYRK1ACLK3TGFBR1
SCHEMBL17568593 0.90 WNT1 (0.61) WNT1CLK2DYRK1ACLK3TGFBR1
SCHEMBL20455343 0.90 CLK2 (0.56) WNT1CLK2DYRK1ACLK3TGFBR1
SCHEMBL17591966 0.90 WNT1 (0.64) WNT1CLK2DYRK1ACLK3TGFBR1
SCHEMBL17592448 0.90 WNT1 (0.72) WNT1CLK2DYRK1ACLK3TGFBR1
SCHEMBL17592023 0.89 WNT1 (0.68) WNT1CLK2DYRK1ACLK3TGFBR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016040184-A1 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2016-03-17 — — WO claimed
US-20180201624-A1 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF VICKERS-SPLICE CO-INVESTMENT LLC (KY) 2018-07-19 — — US disclosed
US-20180201624-A1 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF VICKERS-SPLICE CO-INVESTMENT LLC (KY) 2018-07-19 — — US disclosed
US-9815854-B2 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridine and therapeutic uses thereof SAMUMED, LLC (US) 2017-11-14 — — US disclosed
US-9815854-B2 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridine and therapeutic uses thereof SAMUMED, LLC (US) 2017-11-14 — — US disclosed
US-20170260209-A1 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF VICKERS-SPLICE CO-INVESTMENT LLC (KY) 2017-09-14 — — US disclosed
US-20170260209-A1 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF VICKERS-SPLICE CO-INVESTMENT LLC (KY) 2017-09-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180201624-A1 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF WNT3, WNT1, WNT3A WNT1 2/4885CLK2 2431/4885DYRK1A 994/4885
US-20170260209-A1 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF WNT3, WNT1, WNT3A WNT1 2/4885CLK2 2431/4885DYRK1A 994/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.