Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 14/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17593243 | 0.83 | KDM4E (0.62) | PHGDHALDH1A1KDM4EMAPT | |
| SCHEMBL17593069 | 0.79 | TDP1 (0.58) | PHGDHALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL17592954 | 0.78 | PHGDH (0.50) | PHGDHALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL17593247 | 0.77 | TSHR (0.59) | PHGDHALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL31610139 | 0.75 | PHGDH (0.64) | PHGDHALDH1A1KDM4ELMNA | |
| SCHEMBL28124044 | 0.75 | MAPT (0.62) | PHGDHALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL26673912 | 0.74 | MAPT (0.62) | MAPT | |
| SCHEMBL17593103 | 0.74 | PHGDH (0.43) | PHGDHKDM4EMAPT | |
| SCHEMBL26673830 | 0.74 | MEN1 (0.60) | PHGDHALDH1A1MAPT | |
| SCHEMBL9967797 | 0.74 | CA1 (0.64) | ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |