Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.53 |
| ▸ | DPP4 | P27487 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PHGDH | O43175 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17593069 | 0.89 | TDP1 (0.58) | KDM4EKMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL17593156 | 0.88 | KMT2A (0.57) | KDM4EKMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL17593269 | 0.88 | MAPK1 (0.60) | KDM4EKMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL17593272 | 0.87 | KDM4E (0.54) | KDM4EKMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL17593082 | 0.87 | KDM4E (0.54) | KDM4EKMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL17593238 | 0.87 | THRB (0.56) | KDM4EKMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL17593206 | 0.86 | KDM4E (0.53) | KDM4EKMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL17592953 | 0.83 | PHGDH (0.59) | KDM4EALDH1A1MAPTPHGDH | |
| SCHEMBL17593247 | 0.83 | TSHR (0.59) | KDM4EKMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL17592902 | 0.82 | KDM4E (0.68) | KDM4EKMT2AMEN1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |