Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | PHGDH | O43175 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17593069 | 0.84 | TDP1 (0.58) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL17593243 | 0.83 | KDM4E (0.62) | SMN1; SMN2MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL17592953 | 0.77 | PHGDH (0.59) | LMNAALDH1A1KDM4EPHGDHMAPT | |
| SCHEMBL17593131 | 0.77 | SMN1; SMN2 (0.69) | TSHRSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL1506599 | 0.76 | TSHR (1.00) | TSHRSMN1; SMN2LMNAMEN1HTT | |
| SCHEMBL17593238 | 0.75 | THRB (0.56) | SMN1; SMN2MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL19346201 | 0.74 | ALDH1A1 (0.50) | TSHRSMN1; SMN2ALDH1A1THRBNPSR1 | |
| SCHEMBL19345867 | 0.74 | ALDH1A1 (0.50) | TSHRSMN1; SMN2ALDH1A1THRBNPSR1 | |
| SCHEMBL19345878 | 0.73 | ALDH1A1 (0.49) | TSHRSMN1; SMN2LMNAALDH1A1THRB | |
| SCHEMBL17592960 | 0.73 | LMNA (0.69) | TSHRSMN1; SMN2LMNAMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |