Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1757597 | 0.74 | LMNA (0.66) | KEAP1NFE2L2HTR2AHTR2CHTR7 | |
| SCHEMBL31105587 | 0.70 | MAP3K14 (0.60) | HTR2AHTR2CHTR7HTR6KDM4E | |
| SCHEMBL1757669 | 0.69 | PTGDR2 (0.61) | MEN1KMT2A | |
| SCHEMBL27681973 | 0.69 | PTGS2 (0.59) | KEAP1NFE2L2HTR2AHTR2CHTR7 | |
| SCHEMBL8127718 | 0.68 | KDM4E (0.57) | KEAP1NFE2L2HTR2AHTR2CHTR7 | |
| SCHEMBL11468572 | 0.68 | LMNA (0.62) | KEAP1NFE2L2LMNASMN1; SMN2KDM4E | |
| SCHEMBL30356394 | 0.67 | MAPT (0.55) | KEAP1NFE2L2HTR2AHTR2CHTR7 | |
| SCHEMBL10067335 | 0.67 | MAPT (0.55) | KEAP1NFE2L2HTR2AHTR2CHTR7 | |
| SCHEMBL25805760 | 0.67 | KIF11 (0.55) | KEAP1NFE2L2HTR2AHTR2CHTR7 | |
| SCHEMBL6824373 | 0.67 | NISCH (0.55) | KEAP1NFE2L2HTR2AHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011055270-A1 | INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS | WYETH LLC (US) | 2011-05-12 | — | — | WO | disclosed |