Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDE | P14735 | 1/20 | 0.69 |
| ▸ | PHGDH | O43175 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17593329 | 0.87 | IDE (0.68) | IDEPHGDHKMT2AMEN1MAPT | |
| SCHEMBL17593234 | 0.86 | IDE (0.67) | IDEPHGDHKMT2AMEN1MAPT | |
| SCHEMBL17593316 | 0.84 | IDE (0.67) | IDEPHGDHKMT2AMEN1MAPT | |
| SCHEMBL17593117 | 0.84 | PHGDH (0.81) | IDEPHGDHKMT2AMEN1MAPT | |
| SCHEMBL17593045 | 0.82 | IDE (1.00) | IDEPHGDHKMT2AMEN1MAPT | |
| SCHEMBL17593266 | 0.79 | IDE (0.60) | IDEPHGDHKMT2AMEN1MAPT | |
| SCHEMBL17593104 | 0.76 | MEN1 (0.76) | IDEPHGDHKMT2AMEN1MAPT | |
| SCHEMBL17593240 | 0.72 | NPC1 (0.60) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL17592960 | 0.72 | LMNA (0.69) | IDEPHGDHKMT2AMEN1MAPT | |
| SCHEMBL17593284 | 0.71 | KMT2A (0.62) | KMT2AMEN1MAPTHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |