Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDE | P14735 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.66 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.66 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.64 |
| ▸ | RAC1 | P63000 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PHGDH | O43175 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17593188 | 0.82 | IDE (0.69) | IDEKMT2AMEN1POLBMAPT | |
| SCHEMBL17593329 | 0.81 | IDE (0.68) | IDEKMT2AMEN1POLBMAPT | |
| SCHEMBL17593316 | 0.80 | IDE (0.67) | IDEKMT2AMEN1POLBMAPT | |
| SCHEMBL17593117 | 0.80 | PHGDH (0.81) | IDEKMT2AMEN1POLBMAPT | |
| SCHEMBL17593234 | 0.80 | IDE (0.67) | IDEKMT2AMEN1POLBRAC1 | |
| SCHEMBL17593266 | 0.75 | IDE (0.60) | IDEKMT2AMEN1POLBMAPT | |
| SCHEMBL17592960 | 0.73 | LMNA (0.69) | IDEKMT2AMEN1POLBMAPT | |
| SCHEMBL17593104 | 0.72 | MEN1 (0.76) | IDEKMT2AMEN1RAC1MAPT | |
| SCHEMBL17593267 | 0.71 | L3MBTL1 (0.57) | IDEKMT2AMEN1POLBMAPT | |
| SCHEMBL19345895 | 0.70 | IDE (0.54) | IDEKMT2AMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | claimed |
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |