Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfameter. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | DHFR | P00374 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfameter SCHEMBL79417 | 0.98 | LMNA (1.00) | LMNAAURKADHFRTSHRHTR6 | |
| Sulfameter SCHEMBL11137116 | 0.97 | LMNA (0.97) | LMNAAURKADHFRTSHRHTR6 | |
| Sulfameter SCHEMBL27709233 | 0.97 | LMNA (0.97) | LMNAAURKADHFRTSHRHTR6 | |
| Sulfameter SCHEMBL28250749 | 0.93 | LMNA (0.89) | LMNAAURKADHFRTSHRHTR6 | |
| Sulfameter SCHEMBL7614372 | 0.88 | LMNA (0.81) | LMNAAURKADHFRTSHRHTR6 | |
| Sulfameter SCHEMBL28121714 | 0.86 | LMNA (0.77) | LMNAAURKADHFRTSHRMEN1 | |
| SCHEMBL23567060 | 0.83 | LMNA (0.73) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| Sulfaperin SCHEMBL9418724 | 0.83 | LMNA (0.68) | LMNAAURKADHFRTSHRMEN1 | |
| Sulfametomidine SCHEMBL13723980 | 0.83 | LMNA (0.70) | LMNAAURKADHFRTSHRHTR6 | |
| SCHEMBL2178392 | 0.82 | LMNA (0.72) | LMNAHTR6MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |